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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VCP All Species: 50.3
Human Site: Y495 Identified Species: 92.22
UniProt: P55072 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55072 NP_009057.1 806 89322 Y495 E L Q E L V Q Y P V E H P D K
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_852626 806 89284 Y495 E L Q E L V Q Y P V E H P D K
Cat Felis silvestris
Mouse Mus musculus Q3UMC0 893 97237 S612 G M N D I R P S A M R E V A I
Rat Rattus norvegicus P46462 806 89330 Y495 E L Q E L V Q Y P V E H P D K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520419 805 89553 Y494 E L Q E L V Q Y P V E H P D K
Chicken Gallus gallus NP_001038129 806 89306 Y495 E L Q E L V Q Y P V E H P D K
Frog Xenopus laevis P23787 805 89193 Y495 E L Q E L V Q Y P V E H P D K
Zebra Danio Brachydanio rerio Q7ZU99 806 89405 Y495 E L Q E L V Q Y P V E H P D K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KN62 801 88841 Y492 E L Q E L V Q Y P V E H P D K
Honey Bee Apis mellifera XP_392892 800 88877 Y492 E L Q E L V Q Y P V E H P D K
Nematode Worm Caenorhab. elegans P54812 810 89622 Y500 E L Q E L V Q Y P V E H P E K
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LZF6 810 89940 Y498 E L Q E T V Q Y P V E H P E K
Baker's Yeast Sacchar. cerevisiae P25694 835 91977 Y505 E L K E T V E Y P V L H P D Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 99.8 N.A. 38.5 99.8 N.A. 97.8 99 96.6 96.7 N.A. 83.1 83.6 78.7 N.A.
Protein Similarity: 100 N.A. N.A. 99.8 N.A. 57.1 100 N.A. 98.3 99.7 98.8 98.7 N.A. 92 93 89.2 N.A.
P-Site Identity: 100 N.A. N.A. 100 N.A. 0 100 N.A. 100 100 100 100 N.A. 100 100 93.3 N.A.
P-Site Similarity: 100 N.A. N.A. 100 N.A. 26.6 100 N.A. 100 100 100 100 N.A. 100 100 100 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 77.1 67.5 N.A.
Protein Similarity: N.A. N.A. N.A. 87.6 83.2 N.A.
P-Site Identity: N.A. N.A. N.A. 86.6 66.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 93.3 86.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 8 0 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 0 0 0 0 0 0 0 0 77 0 % D
% Glu: 93 0 0 93 0 0 8 0 0 0 85 8 0 16 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 93 0 0 0 % H
% Ile: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 8 % I
% Lys: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 85 % K
% Leu: 0 93 0 0 77 0 0 0 0 0 8 0 0 0 0 % L
% Met: 0 8 0 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 8 0 93 0 0 0 93 0 0 % P
% Gln: 0 0 85 0 0 0 85 0 0 0 0 0 0 0 8 % Q
% Arg: 0 0 0 0 0 8 0 0 0 0 8 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 16 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 93 0 0 0 93 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 93 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _